Identifying novel gene regulatory networks that drive human hematopoietic stem cell expansion

Hematopoietic stem cell transplantation (HCT) is a critical treatment for over 30 serious diseases, including blood cancers and genetic disorders. It relies on hematopoietic stem cells (HSCs), which regenerate the blood and immune systems. These cells can be collected from bone marrow, cord blood, or mobilized peripheral blood, and may come from the patient (autologous) or a donor (allogeneic). While autologous transplants have higher survival rates, they aren’t always possible. A major challenge is obtaining enough CD34+ stem cells for a successful transplant. Sometimes, one donor isn’t enough, and combining multiple donors raises the risk of complications like graft-versus-host disease. To address this, scientists are working on ways to expand stem cells outside the body before transplantation (ex vivo expansion). This proposal will decipher how a gene called ALKBH5 controls hematopoietic stem cell (HSC) expansion, and identify the underlying pathways the control HSC expansion and engraftment. This could improve safety and effectiveness, especially with smaller grafts.

Faculty Supervisor:

Theodore Perkins

Student:

Partner:

Canadian Blood Services (ON)

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology; Manufacturing; Professional, scientific and technical services

University:

University of Ottawa

Program: