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In vivo screening of interactions between glycans and immune cells
The proposed Research Plan is to evaluate the active targeting effect of glycan ligands for the delivery of conjugated lipid nanoparticles (LNPs) to human bone marrow CD34 + hematopoietic stem and pluripotent cells (HSPCs) and human peripheral blood mononuclear cells (PBMCs) such as T cells and B cells. A reporter mRNA will be formulated into LNPs with or without glycan ligand conjugation. The activity of these LNPs will be assessed both in vitro and in vivo.
Faculty Supervisor:
Matthew Macauley;Ratmir Derda
Student:
Partner:
48 Hour DIscovery
Discipline:
Life Sciences
Sector:
Professional, scientific and technical services
University:
University of Alberta
Program:
Accelerate
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