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Innovations in Mass Cytometry
Biological systems are exceptionally complex. To understand the biochemical processes that influence diseases in whole organisms, information about all the cell types present and their activities is required. Mass cytometry is a Canadian invention that enables the simultaneous quantification of a large number of parameters at the cellular level in heterogeneous biological samples. Mass cytometers and their associated reagents are currently produced in Markham, ON by Standard BioTools Canada Inc., our partner on this application. The goal this project is to leverage the unique capabilities of Mass Cytometry to demonstrate valuable measurements that are impossible by other technologies. We will demonstrate how common methods of analyzing tissue in two colours can be done with over 40 colours. We will show an example of how we can find which cells in a complex mixture take up and bind to a drug. Finally we will show how following the response of all cells to a drug simultaneously will reveal selective approaches to target specific immune cells.
Faculty Supervisor:
Mark Nitz
Student:
Partner:
Standard Biotools Canada Inc.
Discipline:
Life Sciences
Sector:
Professional, scientific and technical services
University:
University of Toronto
Program:
Accelerate
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Mitacs is funded by the Government of Canada, the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of New Brunswick, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon.