Investigating Cfp1 PHD Domain Iron–Sulfur binding activity in anaerobic conditions through Structural and Biochemical Studies

This project aims to uncover how Cfp1 PHD domain, a chromatin reader domain traditionally known for coordinating zinc might use a special iron–sulfur (Fe–S) cluster to sense and respond to changes in the cell’s environment. By studying this protein under oxygen-free conditions and determining its 3D structure, we hope to reveal how redox chemistry influences gene regulation, a question with broad implications for understanding cell function and disease. The project brings together the University of Ottawa’s expertise in chromatin biology and the Institute of Structural Biology in Grenoble’s world-leading specialization in metalloproteins. This collaboration will advance understanding of redox-linked chromatin regulation while strengthening the partnership between the University of Ottawa and the Institute of Structural Biology through shared infrastructure, training, and joint publications.

Faculty Supervisor:

Jean-Francois Couture

Student:

Partner:

Institut de Biologie Structurale

Discipline:

Life Sciences

Sector:

Life Sciences (not health)

University:

University of Ottawa

Program: