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L2M: Closed-loop vancomycin monitoring and delivery
This project aims to advance the commercialization strategy of a closed-loop microneedle-based biosensing platform for real-time therapeutic drug monitoring. The technology integrates hydrogel microneedles with electrochemical aptamer-based sensors to continuously measure drug concentrations in interstitial fluid and enable adaptive dosing. Initially developed for vancomycin monitoring, the platform addresses critical limitations of conventional therapeutic drug monitoring, including delayed laboratory results, invasive blood sampling, and population-based dosing models that do not reflect patient-specific pharmacokinetics.
Faculty Supervisor:
Mahla Poudineh
Student:
Partner:
Innovation Factory
Discipline:
Engineering
Sector:
Professional, scientific and technical services
University:
University of Waterloo
Program:
Business Strategy Internship
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Mitacs is funded by the Government of Canada, the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of New Brunswick, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon.