L2M QC Spring 2025 | A High-Throughput Platform for Ribomodule Selection and Optimization in Therapeutic RNA

This project aims to assess the market potential of a platform for producing ribomodules, specialized RNA fragments designed to enhance the stability, expression control, and functionality of therapeutic RNA (ARNth). The platform leverages high-throughput screening to develop tailored ribomodules that regulate gene expression and improve RNA stability through optimized circularization. While these innovations hold great promise for overcoming key challenges in RNA therapeutics, such as degradation and off-target effects, their commercial viability remains uncertain.

Through the Lab2Market Validate (L2M Validate) program, this study will engage with biopharmaceutical companies, researchers, and industry stakeholders to evaluate whether the proposed ribomodule platform aligns with real-world market needs. Key questions include whether companies perceive a need for internal RNA regulation mechanisms, how they currently address RNA stability issues, and whether customized ribomodules provide a competitive advantage over existing solutions. By bridging the gap between scientific innovation and commercial feasibility, this project will validate market demand, refine the business strategy, and explore potential paths to commercialization, whether through licensing, partnerships, or direct adoption by biotech firms.

For V1 Studio, this initiative aligns with its mission to support the transition of cutting-edge research into viable businesses. By guiding the market validation process, V1 Studio will strengthen its role in biotech entrepreneurship and help shape the commercialization roadmap for an emerging RNA technology. The insights gained will not only inform the development of this specific platform but also contribute to broader strategies for translating RNA-based innovations into impactful therapies.

Faculty Supervisor:

Jonathan Perreault

Student:

Partner:

V1 Studio

Discipline:

Life Sciences

Sector:

Biotechnology; Health and Related Sciences & Technology

University:

Université du Québec : Institut national de la recherche scientifique

Program: