Related projects
Discover more projects across a range of sectors and discipline — from AI to cleantech to social innovation.
Mechanisms and physiological significance of iron overload induced adiponectin resistance in skeletal muscle
To investigate whether IO alters skeletal muscle adiponectin sensitivity and the mechanisms involved. 1. We will use L6 skeletal muscle cells treated with iron to determine if excess iron leads to adiponectin resistance. 2. We will examine temporal regulation of i) NLRP3 inflammasome and ii) oxidative stress by IO and using gain or loss of function approaches we will examine their significance in mediating effects of IO on adiponectin resistance. 2. Using a mouse model of IO we will examine changes in skeletal muscle adiponectin sensitivity as well as mechanisms involved as in i-ii above.
Faculty Supervisor:
Gary Sweeney
Student:
Partner:
Seoul National University
Discipline:
Life Sciences
Sector:
Education
University:
York University
Program:
Globalink Research Award
Current openings
Find the perfect opportunity to put your academic skills and knowledge into practice!
Find Projects
International
Load More
International
Load More
