Multiple functional nanoscale MOF particles for anticancer drug and siRNA delivery system

Nanomaterials as carriers are very suitable for the delivery of chemotherapeutic drugs in cancer treatment. Because nanomaterials as a carrier platform have strong permeability and retention delay in the treatment of tumors, they can passively target tumor cells. Metal organic framework ?MOF ?is a kind of porous material with large pore size and high specific surface area, which can achieve drug encapsulation. We adjusted the size and morphology of MOF to obtain biocompatible materials with an average particle size of less than 200nm. The surface of MOF was further modified to design a nano MOF@drug system combining chemotherapy, photodynamic therapy and gene therapy.

Faculty Supervisor:

Pu Chen

Student:

Feng Zhao

Partner:

Enerclean Technology Ltd

Discipline:

Engineering - chemical / biological

Sector:

Manufacturing

University:

University of Waterloo