New insights into immunomodulatory effects of Spirulina in vitro, and on local and systemic adaptation to high-intensity exercise in horses

Exercise induced inflammation and subsequently free radical production are necessary for exercise recovery. However, excess inflammation may be detrimental to exercise performance and can contribute to degenerative inflammatory conditions such as arthritis in equine athletes. Algae, specifically Spirulina, has the potential to reduce the risk of degenerative disease without impeding post-exercise recovery and adaptation. Spirulina has antioxidant, anti-inflammatory, and immunomodulatory effects that have been demonstrated in human, canine and rodent models of inflammatory stress. The main objective of this study is to quantify direct effects of spirulina on cartilage responses to simulated exercise stress (dynamic compression and hypoxia) with respect to outcomes relevant to degenerative cartilage disease. Data generated in this first study will inform outcome measures to be quantified in a follow-up study exploring inflammatory responses of spirulina-supplemented horses exercising at high-intensity. Our research partner (Selected Bioproducts Inc) will use the data generated from this study to design and market a new feed supplement for horses which will modulate post-exercise local (cartilage) inflammation whilst facilitating systemic recovery from exercise.

Faculty Supervisor:

Wendy Pearson

Student:

Partner:

Selected Bioproducts Inc.

Discipline:

Life Sciences

Sector:

Manufacturing

University:

University of Guelph

Program: