Sernova’s Cell Pouch SystemTM: next-generation preclinical development and assessment of engraftment efficiency in clinical islet transplantation

Next generation preclinical development (caspase inhibitors, stem cell evaluation) and islet metabolic engraftment efficiency in a Phase I/II clinical study of the Cell Pouch™ for islet transplantation in Type 1 diabetes. (The Cell Pouch System™ is a proprietary non-biodegradable polymer device designed by biologists, scientists and engineers which unobtrusively fits under the skin, rapidly incorporating with tissue and microvessels to form a natural environment for engraftment of islets to provide a tight feedback system allowing insulin release for glucose control in diabetics. The scalable Cell Pouch™ has undergone successful initial preclinical proof of concept testing and has been contract manufactured for small and large animal and human clinical evaluation (sentinel and full size pouches).

Faculty Supervisor:

James Shapiro

Student:

Partner:

Sernova Corp

Discipline:

Life Sciences

Sector:

Manufacturing

University:

University of Alberta

Program: