Study of the synergistic effect of two phenolic compounds (Eugenol and Carnosol) and Cisplatin in the treatment of oral cancer

Our project is to discover a more effective way to treat oral cancer that includes Eugenol and Carnosol and its derivatives that are effective in treating different types of cancer and also examining their beneficial (preventive and therapeutic) effects.

The specific objectives:

1) To study the antimicrobial and anti-inflammatory effects of these two compounds as well as its effect on the reinforcement of the defense system of the normal gingival cell (preventive aspect).

2) To study in vitro the therapeutic effect of Eugenol and Carnosol alone or in combination with cisplatin in oral cancer: To study the effect of this combination on

a) Proliferation of oral cancer cells.

b) Apoptosis of oral cancer cells.

c) Cell migration

d) On the autophagy of oral cancer cells

e) Telomerase activity as this telomeric activity has attracted much attention both as a diagnostic marker and as a therapeutic target in oncology.

3)Improve the quality of oral health.

Faculty Supervisor:

Abdelhabib Semlali

Student:

Partner:

Paris-East Créteil University

Discipline: