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Targeting tumour associated macrophages with vaccinia virus to promote anti-tumour immune responses
Virus based therapies represent a powerful new tool in the fight against cancer. However, to ensure their safety and efficacy, we need a better understanding of how these new therapies activate our immune system to help eliminate tumours. These studies include three internships which will: 1) investigate how the vaccinia virus activates immune cells in the tumour, 2) determine how this activation contributes to the therapeutic activity of this virus in treating cancer, and 3) develop new 3D models to investigate the mechanisms by which the physical
features of a tumor determine the effectiveness of these responses. This work will benefit Turnstone Biologics by providing important new insights into how the virus regulates immune cells in the tumour and will provide a variety of tools and systems that can used to test the effects of new candidate treatments on immune function in the tumour.
Faculty Supervisor:
Edana Cassol
Student:
Partner:
Turnstone Biologics
Discipline:
Life Sciences
Sector:
Professional, scientific and technical services
University:
Carleton University
Program:
Accelerate
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Mitacs is funded by the Government of Canada, the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of New Brunswick, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon.