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The effects of exercise intensity on cognitive function in people with Parkinsons Disease
This study explores how cycling at different intensities affects cognitive performance, brain blood flow, and certain blood markers related to brain health in people with PD. We will compare results from individuals with PD to healthy adults of the same age and sex. From this, we can better understand how exercise influences these measures. Proteins of interest include both Brain Derived Neurotropic Factor and ?-Klotho protein, as they have previously been seen to play a role in protecting against cognitive decline. Participants will complete three testing visits: one without exercise, one with moderate-intensity cycling, and one with high-intensity cycling. We will test memory, attention, and visuospatial abilities, as well as brain blood flow and blood protein levels before and after each session. Our goal is to identify the most effective exercise intensity for boosting brain health in people with PD. These findings could lead to better exercise recommendations and identify biological markers effected by exercise that play a role in aging.
Faculty Supervisor:
Philip Millar
Student:
Partner:
Parkinson Society Southwestern Ontario
Discipline:
Life Sciences
Sector:
Other services (except public administration)
University:
University of Guelph
Program:
Accelerate
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Mitacs is funded by the Government of Canada, the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of New Brunswick, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon.