Validation of the tissue regenerative properties of a novel peptide using a cellular co-culture model

This project addresses untreated dental caries, the world’s most prevalent disease affecting over 2 billion people, particularly underserved populations. The research will validate a novel peptide therapeutic that simultaneously promotes dental tissue regeneration and controls inflammation in infected tooth pulp. Using advanced cellular co-culture systems that mimic the inflammatory environment of dental infections, the study will investigate how this peptide activates regenerative pathways while modulating immune responses. This work represents a critical step toward developing a first-in-class biological treatment that could preserve inflamed dental tissues currently requiring removal, offering a transformative alternative to conventional interventions. Successful validation could establish a new paradigm for regenerative treatments in dentistry with broader applications across multiple inflammatory conditions affecting stem cell-rich tissues.

Faculty Supervisor:

Prasanna Neelakantan

Student:

Partner:

The University of Hong Kong

Discipline:

Life Sciences

Sector:

Health and Related Sciences and Technology; Biotechnology; Pharmaceuticals

University:

University of Alberta

Program: