Autoévaluation par les patients des résultats de l’implantation d’un défibrillateur à synchronisation automatique implanté (DSAI)

Le défibrillateur à synchronisation automatique implanté (DSAI), un dispositif qui peut sauver des vies en prévenant la mort subite due à l’arythmie cardiaque, est implanté chez les personnes ayant subi un arrêt cardiaque et, de plus en plus, chez ceux qui souffrent d’insuffisance cardiaque aiguë à risque d’arythmie ventriculaire primaire. En dépit de ses avantages […]

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Best Practice Framework for Healthcare Innovation Infrastructure, Implementation and Learning Campus

This study focuses on identifying best practices to guide the development of the PHC healthcare innovation and learning campus. PHC and the UBC research team seeks to build a design structure matrix (DSM) to inform the PHC about governance, key process, organizing structures, operating practices, intellectual property (IP), partnering approaches, partnership agreements, and implementation plans […]

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Eng/aging and HIV: Knowledge Exchange Between Administrative Data Project and Aging Individuals with HIV/AIDS in British Columbia

To an unprecedented degree in the history of HIV/AIDS, people with HIV/AIDS (PLHIV) are aging largely owing to the success of treatment. As a relatively new phenomenon, research on HIV/AIDS and aging is only just emerging, and remains largely epidemiological in focus. One leading epidemiological study called COAST comes from the B.C. Centre for Excellence […]

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Multi-SNP prediction model for lung function decline

Chronic obstructive pulmonary disease (COPD) is a 3rd leading cause of death (1) which decreases lung function due to irreversible airway obstruction. The main indicator of the progression of COPD is a rate of the forced expiratory volume of 1 second (FEV1) decline. The intern will build the prediction model for the slope of FEV1 […]

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Rational Nanoparticle Design for Efficient Transmucosal Gene Delivery

Cystic fibrosis (CF) is the most common fatal genetic disease affecting Canadian children and young adults, without a cure. Nanoparticles (NPs) have emerged as a promising strategy for delivering genetic treatments for various diseases. However, the development of NPs to treat CF has encountered many obstacles. This is mostly because the human airways, which constantly […]

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Improved Phenotyping of Macrophages Using Cell Line Models, Gene Expression Signatures, and Protein Secretion Data

Chronic obstructive pulmonary disease (COPD) is a 3rd leading cause of death, which decreases lung function due to irreversible airway obstruction. Lung immune cells, such as macrophages, play an important role in the disease progression. However, researchers don’t fully understand their diversity and functions. Models of macrophages are useful to better understand patient macrophages. We […]

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Deep Immunophenotyping of the Immune Response in Obstructive and Interstitial Lung Disease: Optimizing a Cellular and Protein Biomarker Discovery Pipeline for Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF), is a chronic debilitating lung disorder that affects thousands of Canadians and millions of individuals worldwide. The signs and symptoms of IPF often overlap with other common respiratory illnesses making a definitive diagnosis of this disease difficult. As a result, patients are frequently misdiagnosed and treated with inappropriate therapies. As such, […]

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Developing a surrogate marker to asthmatic tissue: the nasal cavity

Our research proposal will explore the unified airway theory and determine whether the sinuses express biological similarities to the lungs in participants who only clinically present with Chronic Rhinosinusitis (CRS)or asthma and not with both diseases. The unified airway theory suggests that the lower (lungs) and upper (sinuses) airways are intrinsically connected and function together […]

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Patient-reported outcomes of individuals living with an implanted cardioverter defibrillator

Implantable cardioverter defibrillators (ICD), life‐saving devices that may prevent sudden cardiac death from cardiac arrhythmias, are implanted in people who have had cardiac arrests and increasingly in people with severe heart failure who are at risk for a primary ventricular arrhythmia. The clinical benefits of ICD implantation contrasts with evidence suggesting ICDs may also have […]

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Investigation of the role of macrophage and smooth muscle cell sub-phenotypes in human atherosclerosis

Providence Healthcare has established a reputation as one of the leading centres for cardiovascular research and treatment in Canada. Pfizer Global Pharmaceuticals Canada is a major provider of pharmaceuticals used in cardiovascular treatment, and has an active research agenda aimed at improving the effectiveness of non]invasive diagnosis and treatment in this field. Pfizer and Providence […]

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A Critical Pathway for Cardiac Defibrillators in Patients with Ischemic Cardiomyopathy

Providence Health Care has established a reputation as one of the leading centres for cardiology research and treatment in Canada. Medtronic of Canada is a major supplier of therapeutic cardiac equipment, technology and implantable devices, and works closely with Providence Healthcare to advance the science of cardiac treatment. Providence Health Care and Medtronic of Canada […]

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