Our immune system Is designed to protect us from harmful agents. It must initiate a rapid potent inflammatory response to eliminate invading pathogens. Although similar to the eradication of pathogens, the inflammatory response can also occur following a sterile injury and is required for tissue repair and wound healing. This includes trauma, ischaemia-reperfusion injury, autoimmunity […]

The proposed study has three objectives: Objective 1. Develop KOA microsimulation model: To develop and validate a Knee-OA population-based microsimulation model (POHEM-KOA) using the previously developed POHEM-OA model. Objective 2. Perform cost-effectiveness analysis of non-pharmacological therapies for KOA: To use POHEM-KOA in conducting a cost-effectiveness analysis of treatment strategies, including exercise therapy and weight reduction, […]

Prolonged morphine treatment is known to cause an up-regulation of ORL1 receptors in the spinal cord (12, 13), which in turn is believed to contribute to the development of morphine tolerance by altering ?-opioid receptor mediate modulation of N-type calcium channels. Indeed, ORL1 antagonists can reverse the development of tolerance, and ORL1 knockout can mediate […]

Cardia Resynchronization Therapy (CRT) is aq pacing therapy used to reduce symptoms and mortality in patients with heart failure. It delivers a specialized pacing lead to the left ventricle (LV) through the coronary veins to re-synchronize the contraction of the heart when it has become delayed or desynchronous. However its benefit has proved to be […]

The long-term research goal of the research group is to contribute to the fundamental state-of-knowledge on gas hydrates by improving methodologies and techniques for characterization, assessment, and development of natural gas hydrate accumulations. The short-term goal and main objective of the present proposal is to characterize and assess submarine geohazards evolving from gas hydrate instability. […]

We have developed a software tool that could be used as stand-alone software, or could be implemented in a vascular diagnostic suite (for example within the post-processing software that accompanies most CT and MR scanners). The tool would allow surgeons and radiologists to better evaluate the current state of the aorta under examination and the […]

The objectives of this study are: • To assess the feasibility of using satellite remote sensing technology to measure trace gases and aerosols over northern Alberta and to study the transport of biomass burning emissions and its impact on air quality over northern Alberta. Methodology: Data from several satellite sensors will be used in this […]

Functional electrical stimulation (FES) exercise therapy (ET) is well established in the scientific community (Teasell et al, 2007 and http://www.ebrsr.com/ ) yet it is not accessible to the majority of the stroke population or those that could greatly benefit from it. In Canada alone millions of dollars has been spent in the last 20 years […]

The research project identified here falls under the category of “clean energy technology”. Methanobiofiltration (MBF) is a new technology for the treatment of waste methane gas using a biological process, thus contributing to the reduction of the environmental impacts of current energy technologies. The lack of a complete technology package needed for various industry sectors […]

From the survey of literature (Eames et al. (1995), Chunnanond & Aphornratana (2004b), Chunnanond & Aphornratana (2004a) and others), the performance of a jet refrigeration system depends greatly on the ejector configuration (characteristics). Many researchers have shown the need to improve performance in order to make ejector-based cooling economically more attractive. It is known that […]

Phase I: Development of Intellectual Property to Facilitate Partnership Agreements with Business and Non-profit Organization Before partnership agreements with the business sector (companies) and not-for-profit organizations can be undertaken, intellectual property rights need to be established. Thus, we will first develop and validate GaitreminderTM as a method for evaluating gait abnormalities in normal ageing and […]

The broad objectives of this project are: I. To reduce the risk of emerging infectious diseases related to poultry; and II. To improve Alberta poultry industry productivity and profitability To reach these broad objectives we will address 3 specific objectives: 1) Determine what the knowledge needs of the poultry industry are and how knowledge is […]