Hyperpolarized 129Xe Cerebral Perfusion MRI Imaging Development

Imaging of cerebral perfusion (the delivery of blood to a capillary bed in the brain tissue) is significant for diagnosing a variety of diseases. There are multiple challenges associated with perfusion imaging which significantly limits the quality of cerebral perfusion images. I am planning to develop a novel approach of cerebral perfusion magnetic resonance imaging […]

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Development of a new generation of neurovascular device for the treatment of fusiform cerebral bifurcation aneurysms using CFD modeling and virtual simulation of stent crimping into a catheter

Cerebral aneurysm (CA), is an abnormal dilation of the cerebral arterial wall, which accounts for more than half a million deaths each year worldwide. Flow diverters (FDs) represent one method recently developed in treating CAs. Typically, they do not need coiling (releasing platinum micro-coils within the aneurysm) and act purely to prevent substantial blood inflow […]

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Development of a new generation of neurovascular device for the treatment of fusiform cerebral bifurcation aneurysms using CFD modeling and virtual simulation of stent crimping into a catheter – Year two

Cerebral aneurysm (CA), is an abnormal dilation of the cerebral arterial wall, which accounts for more than half a million deaths each year worldwide. Flow diverters (FDs) represent one method recently developed in treating CAs. Typically, they do not need coiling (releasing platinum micro-coils within the aneurysm) and act purely to prevent substantial blood inflow […]

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Evaluation of the implementation at scale of a public health intervention to promote social and emotional development in the early years in British Columbia

British Columbia’s Ministry of Mental Health and Addictions has identified healthy social and emotional development (SED) in early childhood as a priority action towards addressing the province’s mental health crisis. In response, ChildHealth BC (CHBC) is developing a multi-component provincial intervention to expand the capacity of caregivers to promote SED in young children- the first […]

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Comprehensive Molecular Analysis of Pre- and Postmenopausal Human Mammary Cells to Enable Their Optimized Growth as Organoids Ex Vivo

The goal of this project is to discover new factors essential for maintaining a normal human mammary gland. The approach is to generate and analyze in depth the protein-encoding RNAs and chromatin states that control their expression in the different types of cells that constitute the human mammary epithelium and its surrounding stromal cells. This […]

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Comprehensive Molecular Analysis of Pre- and Postmenopausal Human MammaryCells to Enable Their Optimized Growth as Organoids Ex Vivo – Year two

The goal of this project is to discover new factors essential for maintaining a normal human mammary gland. The approach is to generate and analyze in depth the protein-encoding RNAs and chromatin states that control their expression in the different types of cells that constitute the human mammary epithelium and its surrounding stromal cells. This […]

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Visualizing information in situ with 3D photorealistic environments

Advances in computer graphics and display technology have brought new opportunities to create stunning visual effects and interactive experiences. Industry concerned with data visualization is seeking to incorporate these advances into their visualization pipelines. For example, our industrial partner LlamaZOO Interactive Inc. attempts to present abstract data situated in 3D realistic scenes. However, most research […]

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Ensuring Stability and Accuracy of Multi-rate Electromagnetic Transient Simulation

Real-time digital power system simulators are used for testing and debugging control equipment intended for field installation. They simulate the power network in ‘real-time’, i.e., the simulation computations are rapidly completed so as to retain synchronism with a real-world clock. This requires the level of complexity in different components of the network to be judiciously […]

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Synthesis and modeling of stimuli-responsive polymers for fracturing fluids use

Currently, the global warming alerts, oil prices fluctuations and clean energy have paved the way of investing in the producing wells by enhancing the recovery of hydrocarbons compared to exploration wells. Applying hydraulic fracturing from injected fluids is most common method used. These fluids create cracks in the bedrock and push the hydrocarbons to the […]

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Development of a specific targeted therapy for hepatocellular carcinoma

The global burden of hepatocellular carcinoma (HCC) is increasing as it has become the second leading cause of cancer-related deaths and the fifth most common cancer worldwide. HCC is heterogenous, arising in the setting of various chronic liver diseases such as hepatitis C, non-alcoholic fatty liver disease and cirrhosis. Patients with cirrhosis who develop cancer […]

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Development of a specific targeted therapy for hepatocellular carcinoma – Year two

The global burden of hepatocellular carcinoma (HCC) is increasing as it has become the second leading cause of cancer-related deaths and the fifth most common cancer worldwide. HCC is heterogenous, arising in the setting of various chronic liver diseases such as hepatitis C, non-alcoholic fatty liver disease and cirrhosis. Patients with cirrhosis who develop cancer […]

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Engaging young people and fostering intergenerational collaboration: Assessing the impact of initiatives within the nature conservation sector

The International Union for the Conservation of Nature (IUCN) has served as a global authority on sustainable development and environmental governance for over seventy years. Responding to broader trends within these areas, the IUCN has sought to foster engagement with young people as a strategic priority-to move beyond tokenistic involvement toward institution-wide intergenerational collaboration. The […]

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