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Sanofi-Pasteur is developing new vaccine formulations that need to be evaluated on their efficacy and potency. Traditionally, the use of animal models to predict human immunity has been accepted as the best way to select vaccine formulations. However, animal models can be costly and time-prohibitive, and the assays employed to assess vaccine efficacy and potency are not ideal for rapid screening and optimization of multiple formulations. To overcome these limitations, we propose to test new vaccine formulations utilizing laboratory cultured macrophage cells. Vaccine interactions with macrophages ultimately determine the effectiveness of a given formulation.
Mauricio Terebiznik;Roberto J Botelho
Javier Roberto Jaldin-Fincati
Sanofi Pasteur
Biology
Pharmaceuticals
Accelerate
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