Biophysical analysis of ABCG sterol transporters

Our research concerns a group of lipid trafficking proteins, scientifically known as ABC transporters, that only work when submerged in the sea of lipids, which we call membranes. These proteins can pick up lipid molecules, especially sterols, and move the lipids out or into the cells. We know that different members of these lipid trafficking proteins work together to remove different types of sterol molecules, but no one knows exactly how such types of proteins can work on different types of lipid molecules. Our objective of this project is to investigate the molecular factors that determine how such type of protein recognizes and traffics the lipid molecules in cells.

Faculty Supervisor:

Jyh-Yeuan Eric Lee

Student:

Partner:

Academia Sinica

Discipline:

Life Sciences

Sector:

Life Sciences (not health)

University:

University of Ottawa

Program: