Cellular and molecular properties of exosomes derived from keratinocytes differentiated from equine induced pluripotent stem cells (eiPSCs) and bone marrow mesenchymal stem cells (eBM-MSCs)

Regenerative medicine has long faced challenges in the search for alternatives that ensure an effective treatment by accelerating the repair process without altering the physiological phases of healing. It is believed that the utilization of the stem-cell secretoma can benefit injured tissue by modulating the local microenvironment, providing cytoprotectors, anti-inflammatory and angiogenic factors during an acute phase leading to injury and by boosting the stem/progenitor cells residing locally with the aim of obtaining a more specific healing programme through the stimulation of resident endogenous progenitors that are critical for the future development of a paracrine drug therapy. Moreover, studies have demonstrated the repairing role of exosomes from mesenchymal stem cells derived from iPSCs in humans by stimulating cell proliferation/migration, and facilitating the healing of cutaneous wounds by promoting collagen synthesis and angiogenesis. Together, these reports indicate that pluripotent and mesenchymal stem cell exosomes may also play a key role in the equine wound healing process.

Faculty Supervisor:

Lawrence Smith

Student:

Partner:

Universidade de São Paulo

Discipline:

Life Sciences

Sector:

Education

University:

Université de Montréal

Program: