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Determining the effects of gating modifier compounds on cultured central nervous system neurons as potential therapeutics against epilepsy.
Voltage-gated sodium channels are key contributors to excitability in living organisms; hence, modulation of these channels through mutations and/or environmental triggers can often lead to serious disorders. Having an enriched understanding of the sodium channel electrophysiology may result in uncovering potential therapeutic targets. The general aims of our research include studying the effects of various modulators on sodium channels through well-established electrophysiological techniques. These efforts will be an effort to discover potentially therapeutic modulators against sodium channel-mediated epilepsies.
Faculty Supervisor:
Peter Charles Ruben
Student:
Partner:
Xenon Pharmaceuticals Inc
Discipline:
Life Sciences
Sector:
Manufacturing; Professional, scientific and technical services
University:
Simon Fraser University
Program:
Accelerate
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Mitacs is funded by the Government of Canada, the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of New Brunswick, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon.