Formes pharmaceutiques solides gastro-résistantes de la Catalase

Inflammation is an undesirable effect that can be caused by the high level of hydrogen peroxide (H2O2), an oxidant molecule. This inflammation is found mostly in small and large intestines area. Catalase, is a protein (antioxidant agent). It is able to decompose large quantities of H2O2 into water and oxygen and thus, eliminating this harmful molecule.

The project will consist of manufacturing swallowable tablets containing catalase in order to act in the intestine. The tablets pass through the stomach before arriving in the intestine. Tablets must remain intact after they pass through the stomach. For this, the tablets are made with different component able to protect drug against the gastric acidity. To test the tablets in the laboratory, liquids simulating the environment of the human stomach and intestine are used. Different compositions and coatings of the tablets will be tested. In short, the tablets are aimed to reduce the inflammation produced by H2O2 in the intestine. In future perspective, tablets might be used as drugs.

Faculty Supervisor:

Mircea Alexandru Mateescu

Student:

Partner:

Corealis Pharma Inc

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

Université du Québec à Montréal

Program: