Identifying probiotics that modulate mitophagy in models of mitochondrial dysfunction

Mitochondria are critical producers of energy and are the platform for various metabolic reactions that support cellular health. Mitochondria suffer from a variety of damage as a consequence of housing these reactive pathways. In order for cells and organisms to survive this damage, dysfunctional mitochondria are removed from the cell in a process termed mitophagy. The goal of this proposal is to identify probiotics that enhance mitophagy, thereby serving as ideal promoters of health by preserving mitochondrial, cellular and organismal function.

Faculty Supervisor:

Angus McQuibban

Student:

Peter Hawrysh

Partner:

Lallemand Health Solutions

Discipline:

Biochemistry / Molecular biology

Sector:

Life sciences

University:

University of Toronto

Program:

Accelerate

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