In silico design of tumor selective binder for immunotherapy

Precision medicine is showing great promise in the fight against cancer. One of the major hurdles is how to best target cancer cells for destruction while sparing normal ones because both share many of the same attributes or “targets”. However, when cancer grows, tumors create a microenvironment around them, the TME or tumor microenvironment. The chemical conditions inside the TME are markedly different than outside the tumor.
At Modulari-T we have developed a way to program the immune system to recognize and kill cancer cells which we call MARC cells. If these cells are not properly targeted towards cancer, they can cause toxic side effects by attacking normal tissue.
This project proposes to develop a new way to target MARC cells so that they become triggered by the chemical conditions inside the TME and thus spare healthy tissue.

Faculty Supervisor:

Ré Mansbach

Student:

Partner:

Modulari-T Bioscience

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

Concordia University

Program: