Interaction of Cyclin-dependent kinase 2 with CR6-interacting factor 1, and the inhibitor search for such interaction against leukemia treatment resistance

Cyclin-dependent kinase-2 (CDK2) regulates cell cycle, whose structure and biological characteristics are well known. CRIF1 plays a regulatory role in the bone marrow microenvironment-induced leukemia cell cycle arrest through inhibiting CDK2. In this multi-disciplinary research, we will use a combined structure function study to reveal the interaction between CDK2 and CRIF1. This will facilitate the design of inhibitors for the interaction of the two important proteins, for eventual treatment of leukemia.

Faculty Supervisor:

Sheng-Xiang Lin

Student:

Tang Li, Jean-Francois Thériault, Danrong Ye, Xiaoye Sang

Partner:

Pyrovac Inc

Discipline:

Medicine

Sector:

Medical devices

University:

Program:

Accelerate

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