Investigating Effects of Stereoisomerism on Toxicology of Entactogens by Computational Methods

PharmAla have been focusing on developing MDMA (ecstasy) like drug compounds. MDMA assisted psychotherapy for treatment of PTSD received Breakthrough Therapy designation in August 2017. It is currently being evaluated in Phase 3 clinical trials. The toxicological biochemical mechanism of MDMA and MDMA like compounds should be better understood. Because of this gap an extensive literature search will be done in this project. Toxicological mechanism of MDMA and MDMA like drugs will be investigated by computational modeling tools. Novel Analogs synthesized by PharmAla Biotech Inc will form the basis of the research work. The aim is to utilize computational chemistry to predict safety and toxicological properties of the analogs.

Faculty Supervisor:

James Gauld

Student:

Partner:

PHARMALA BIOTECH INC.

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

University of Windsor

Program: