L2M Novel Hybrid Scanless Confocal Fluorescence Microscopy System

Our project introduces a novel hybrid fluorescence microscopy system that merges the strengths of light-sheet and confocal microscopy while eliminating their key limitations. The system is fully scanless, removing the need for any motorized scanning devices—resulting in faster, simpler, and more reliable imaging. It also integrates a signal intensifier to detect weak fluorescence and a microfluidic channel for automated, high-throughput sample handling.

From an academic perspective, this technology enables rapid, high-resolution, and low-phototoxic imaging, ideal for studying cancer cells, microorganisms, and developing tissues. The combination of scanless confocality and light-sheet illumination allows continuous, non-invasive observation of cell behavior, division, and drug response in real time, even in samples with weak fluorescence signals.

From a business perspective, the platform offers a compact, affordable, and user-friendly alternative to existing expensive and complex microscopes. By combining speed, resolution, and automation in one system, it reduces costs, training time, and maintenance—providing strong return on investment for research and clinical users. With the global fluorescence imaging market expected to grow from USD 11 B to 20 B by 2030, this hybrid scanless microscopy system stands as both a scientific innovation and a high-potential commercial product for research, diagnostics, and drug discovery.

Faculty Supervisor:

Nima Tabatabaei

Student:

Partner:

DMZ Ventures Inc

Discipline:

Engineering

Sector:

Professional, scientific and technical services

University:

York University

Program: