NMR Characterization of amyloid beta peptideinteractions with lead compound

This project aims to obtain detailed information on how a potential Alzheimer drug helps to inhibit the
formation of the toxic species associated with the disease. Utilizing magnetic resonance technologies,
we seek to characterize how the drug fits into the toxic species. The steps consist of making the toxic
species, combining it with the drug and generating a structure of the drug bound to the substance.
Knowledge of the shape and arrangements of groups between the species and drug will be used by
Treventis to rationally modify the drug to make it more effective.

Faculty Supervisor:

Ray Syvitski

Student:

Partner:

Treventis Corporation

Discipline:

Life Sciences

Sector:

Manufacturing; Professional, scientific and technical services

University:

Dalhousie University

Program:

Accelerate

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