Pharmacology of psychoactive substances

This project aims to investigate the pharmacology of norbaeocystin, baeocystin, norpsilocin, and aeruginascin – four compounds found in psychedelic mushrooms. The research will examine how these compounds interact with specific brain receptors – the 5HT-1A, sigma-1 and a-adrenergic receptors – that may contribute to the therapeutic effects. These compounds may have potential for the treatment of depression, anxiety, post-traumatic stress disorder and other conditions.
Laboratory testing includes calcium-based assays and ß-arrestin recruitment tests to determine receptor signalling. Compounds demonstrating efficacy in these assays will then be tested. The elevated plus maze test in mice will provide information about the in vivo behavioral effects.

Faculty Supervisor:

Robert Laprairie

Student:

Partner:

Ghent University

Discipline:

Life Sciences

Sector:

Education

University:

University of Saskatchewan

Program: