TRLUP – Advanced Self-Driven Microfluidic Platform for Concentrating Therapeutic Vesicles

We are developing a novel microfluidic platform designed to enable efficient concentration of extracellular vesicles (EVs) from biological fluids such as plasma, serum, etc. This system reduces sample volumes from 1–10?ml down to less than 100?µl without the need for bulky instrumentation or centrifugation, offering a scalable and user-friendly alternative to conventional methods. By leveraging precisely engineered channel geometries and self-driven flow, the platform enhances both yield and purity of EV recovery. This concentrated output is ideal for downstream applications in biomarker discovery, liquid biopsy diagnostics, regenerative medicine, and EV-based therapeutics. The technology builds on our previously validated EV isolation device and incorporates improvements in throughput and handling capacity for integration into clinical and lab workflows. Ultimately, this advancement aims to streamline sample preparation, minimize EV loss, and accelerate translation of EV-based tools into practical healthcare and research settings.

Faculty Supervisor:

Jamie McInnis;Purnima Tyagi

Student:

Partner:

The ETC Foundation

Discipline:

Engineering

Sector:

Professional, scientific and technical services

University:

Southern Alberta Institute of Technology

Program: