Improving environmental effects biomonitoring in freshwater ecosystems: A comparison of morphology-based and DNA-based approaches

Federal Canadian regulations of the Fisheries Act require operating mines and pulp mills to undertake biodiversity monitoring every three years to assess potential environmental effects. Different groups of organisms have differential sensitivity to pollutants and other environmental factors, so communities (e.g., invertebrates) provide a rich source of information about the system’s health Identifying invertebrates using […]

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Évaluer les caractéristiques des fermes laitières produisant des veaux Holstein mieux valorisés dans le secteur du veau lourd.

L’objectif de ce projet est d’évaluer la gestion des veaux laitiers Holstein dans les fermes laitières qui ont un historique de vente de veaux performants en engraissement. À cette fin, une enquête téléphonique est d’abord menée auprès de 150 exploitations laitières. Parmi ces exploitations, 25 seront sélectionnées pour une enquête approfondie à la ferme durant […]

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Design and synthesis of novel influenza M2 proton channel inhibitors with drug resistant antiviral activity

Seasonal influenza causes significant mortality and morbidity worldwide, and we are currently unprepared to mitigate a fatal pandemic outbreak like the 1918 Spanish Flu. A proven influenza antiviral target is the M2 viroporin, or viral ion channel. Amantadine, an M2 inhibitor was an effective antiviral for 20 years. However, current influenza antivirals are increasingly ineffective […]

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Uncovering the role of ketogenesis in SGLT2 inhibitor-mediated fatty liver disease

Fatty liver disease, the most common complication of type 2 diabetes (T2D), affects 1 in 5 Canadians. If not managed or treated, a proportion of patients with fatty liver disease may develop the irreversible phases of liver failure, and hepatocellular carcinoma. A new class of drugs, SGLT2 inhibitors (SGLT2i), has been approved by Health Canada […]

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Développement de vaccins multivalent vivant atténué contre les infections respiratoires causées par les Escherichia coli pathogènes aviaires

Les Escherichia coli pathogènes aviaires (APEC) sont des pathotypes particulièrement importants pour l’industrie avicole, car il provoque la colibacillose, une maladie entraînant des pertes économiques importantes en raison de la mortalité et/ou de la baisse de productivité des oiseaux affectés. Étant donné que plusieurs souches d’APEC sont impliquées dans les épidémies, le développement de vaccins […]

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Peptide-based material for heart muscle repair

With over 17 million deaths per year, heart diseases remain the top cause of mortality worldwide. Surgeries such as bypass restore blood supply and save lives. However, after a heart attack the capacity of the heart to pump blood is reduced. In Canada, over 2 million people aged 20+ live with heart disease, costing the […]

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Development and Evaluation of Antimicrobial Agents for Improving the Lifetime of Metalworking Fluid

Metalworking fluid is a widely used lubricant during the processing of metal (drilling, cutting, grinding, etc.). Even though it has been applied to industries for decades, microbial contamination is still considered a major problem during its application. The microbial contaminations not only reduce the effectiveness of the lubrication but also cause potential health issues. In […]

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Training in bioinformatics, more specifically omics sciences

L’étudiant participera à un entraînement structuré en bioinformatique visant à parfaire ses connaissances de Python et R. Le focus sera placé sur les sciences omiques et ultimement sont projet vise à la détection et l’identification de façon précoce des maladies des plantes, bien que le focus sera initialement placé sur la tomates, une culture importante […]

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Development of novel chemical probes and SARS-CoV-2 antiviral therapeutics through engineered HAI-2 protein inhibitors of TMPRSS proteases

Respiratory viruses exploit the biological activity of human proteins present at the surface of airway cells to allow viruses to penetrate that physical barrier and subsequently replicate in infected cells. It has been established that a family of human proteins, the type 2 transmembrane serine proteases, are directly responsible for this viral entry, but they […]

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In Vivo Validation of a Wireless Fiber Photometry System

Fiber photometry is a powerful method for detecting neural activity or neurotransmitter release in specific brain cells. Doric lenses Inc., in collaboration with Benoit Gosselin’s lab, designed a lightweight, wireless optical recording prototype, which allows fiber photometry recordings in freely behaving animals without the constraints of tether. This new technology provides an innovative tool for […]

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