Effect of exercise training on the human skeletal muscle proteome, phosphoproteome, and proteodynamics

Generally, resistance exercise increases muscle mass and strength, whereas endurance exercise increases the capacity to use fuels and fatigue resistance. In both cases, skeletal muscle translates the physical and biochemical stresses of exercise into morphological and metabolic adaptations, with the adaptations improving one’s ability to perform the corresponding type of exercise. This concept is known as training specificity, and although it makes intuitive sense, the molecular mechanisms that link resistance and endurance exercises with their specific adaptations are not fully understood. How resistance exercise achieves these adaptations remains understudied, but what is known is that skeletal muscle translates the physical and biochemical stresses of resistance exercise into morphological and metabolic adaptations. While both types of exercise activates signaling pathways (i.e., proteins) that increase the synthesis of specific proteins to cause adaptations, thousands of proteins are likely involved, and their interactions are complicated. Until recently, our analytical capacity has limited the number of pathways that could be studied simultaneously; however, using novel molecular techniques, we are examining the entire complement of skeletal muscle proteins in response to resistance exercise.

Faculty Supervisor:

Stuart Phillips

Student:

Partner:

Liverpool John Moores University

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology; Life Sciences (not health)

University:

McMaster University

Program: