This project focuses on improving how we detect Alzheimer’s disease early by measuring lesser-known, protective forms of the amyloid-ß protein—Aß34, Aß37, and Aß38—in blood and cerebrospinal fluid. These shorter forms are thought to help clear the harmful ones that build up in the brain and cause damage. Using a highly sensitive method called single molecule […]

Severe traumatic brain injury (sTBI) is a leading cause of mortality and disability in pediatric populations. Surviving patients often face long-lasting neurological deficits exacerbated by primary and secondary injury, necessitating further advancements in prognosis and understanding of sTBI mechanisms. Our project aims to address this issue by identifying differentially expressed proteins present in pediatric sTBI […]

Le projet Inh’âge vise à comprendre comment les substances odorantes influencent la respiration, en dissociant les composantes olfactives (floral, boisé…) et trigéminées (piquant, frais…) et en examinant l’impact du vieillissement sur ces interactions. L’expérimentation sera réalisée sur deux groupes (jeunes adultes et adultes âgés) et se déroulera en deux phases : la détermination des seuils […]

This project aims to understand how Small Hydropower Plants (SHPs) affects fish assemblages, especially vulnerable young individuals (larvae and juveniles). In this context, we are studying the role of aquatic plants (macrophytes) as their habitat . In addition to inventories of fish taxonomic diversity and we intend to examine how these fish use the environment […]

This project will test how well different DNA-based therapies work in the brain and body using a mouse model. Mice will receive either a high or low dose of the therapy, and their response will be tracked through imaging, blood tests, and tissue analysis. The goal is to measure how much of the DNA reaches […]

This project seeks to develop a non-invasive method, which does not require direct wildlife capture and handling, for monitoring the endangered little brown myotis and a co-occurring species, Yuma myotis, at shared summer maternity roost sites in western North America. A method is urgently needed so that potential species-specific impacts to these two bats from […]

Many patients with mood disorders, which include major depression and bipolar disorder, continue to experience symptoms even after receiving treatment. Traditional research methods have helped improve care but often don’t reflect the realities of clinical practice, which slows progress in applying research to improve services. This project aims to support St. Joseph’s Healthcare Hamilton (SJHH) […]

Our primary mandate at API is to advance basic research and innovation to commercialization by providing access to world-class industry expertise, services, and infrastructure. Our activities focuses on engaging and supporting drug discovery and development initiatives, ensuring compliance with regulatory standards and driving innovation and commercialization through collaborative research and clinical studies. The project aims […]

For decades, dentistry relied on manual processes to create restorations and appliances—methods that are prone to human error, inconsistency, and lengthy production times. 3D printing of dental resins is a transformative technology that is changing how restorations and prostheses are made. 3D printing can integrate with intraoral scanners and CAD/CAM systems to create end-to-end digital […]

Pathogenic biofilms are a major food safety challenge. They are difficult to detect and very difficult to control after they form as biofilms protect bacteria from sanitizers, heat and other stressors that might otherwise be used to control the bacteria. As well, trying to remove the biofilm may break off chunks of biofilm which can […]

Respiratory muscle training (RMT) is a technique used to strengthen the muscles involved in breathing, aiming to improve breathing efficiency and endurance. While there is evidence that RMT can enhance exercise performance, muscle strength, and reduce breathlessness, there is still debate in the field due to the wide variety of devices and methods used. There […]

Digital health technologies (DHTs) are tools and platforms that have the potential to significantly improve patient-centered care in the field of cardiovascular disease (CVD) prevention by providing prolonged monitoring and improving the clinical workflow. Despite numerous advantages, there remains clinician resistance to the implementation of DHTs in healthcare settings. There is an urgent need to […]