CAN-BIND12: Effects of Probiotics on Symptoms of Depression (EPSD)

This study will look at changes in the heart rate variability and electroencephalogram (EEG) signals in individuals receiving gut supplementation for depression. This is to see if the vagus nerve (a major nerve connecting your brain and gut) is affected by this therapeutic, and how that results in changes in your brain. This work will […]

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Predicting players social behaviour in online multiplayer videogames

Online multiplayer videogames are popular because most of their content is generated by interactions among players and thus extremely dynamic. Predicting players’ behaviour in these games is necessary to better design and maintain the game environment and to keep the players engaged in the game. These predictions are difficult because a player’s behaviour varies as […]

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Predicting players social behaviour in online multiplayer videogames – Year two

Online multiplayer videogames are popular because most of their content is generated by interactions among players and thus extremely dynamic. Predicting players’ behaviour in these games is necessary to better design and maintain the game environment and to keep the players engaged in the game. These predictions are difficult because a player’s behaviour varies as […]

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Assessing cumulative effects of development and climate change to inform land use planning in Yukon

The Yukon’s Northern Boreal Mountains region is under increasing pressure from human disturbance and climate change. Exploration of previously untapped natural resources is expanding in northern Canada, and northern ecosystems are thought to be more sensitive to climate stressors[1]. However, the cumulative effects of these co-occurring disturbances on wildlife populations, community structure, and habitat quality […]

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Assessing cumulative effects of development and climate change to inform land use planning in Yukon – Year two

The Yukon’s Northern Boreal Mountains region is under increasing pressure from human disturbance and climate change. Exploration of previously untapped natural resources is expanding in northern Canada, and northern ecosystems are thought to be more sensitive to climate stressors[1]. However, the cumulative effects of these co-occurring disturbances on wildlife populations, community structure, and habitat quality […]

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Investigating the effect of the Virtual Meditative Walk on brain in chronic pain conditions: A longitudinal fMRI study

The Virtual Meditative Walk (VMW) (1) is a well-developed therapeutic protocol that can be used alone or in combination with the Mindfulness-Based Stress Reduction techniques in an Immersive Virtual Reality (IVR) environment. It has been shown to be effective in reducing pain levels in patients with chronic pain (CP); however, little is known about how […]

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Investigating the effect of the Virtual Meditative Walk on brain in chronic pain conditions: A longitudinal fMRI study – Year two

The Virtual Meditative Walk (VMW) (1) is a well-developed therapeutic protocol that can be used alone or in combination with the Mindfulness-Based Stress Reduction techniques in an Immersive Virtual Reality (IVR) environment. It has been shown to be effective in reducing pain levels in patients with chronic pain (CP); however, little is known about how […]

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Community dynamics in restored salt marshes

Salt marshes are important coastal ecosystems that provide many services. Due to their high soil fertility, they have a long history of being converted to farmland. There is now growing interest in restoring salt marshes to protect against coastal erosion, mitigate sea level rise, and provide increased habitat for birds, fish, etc. Ducks Unlimited Canada […]

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Maintaining cell wall integrity in Gram-Negative Bacteria

Pathogenic bacteria have the potential to devastate humanity, and without antibiotics (which are failing), we face a humanitarian crisis. The bacterial cell wall is a principle target of antibiotics, and its understanding is essential to preventing an antibiotic crisis. Our hypothesis is that the process of cell wall peptidoglycan and outer membrane biogenesis must be […]

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Investigating the potential role of algal-derived astaxanthin for improved health and performance in AquAdvantage Salmon – Year two

The rapid expansion of the aquaculture industry has fueled significant advances in fish health and nutrition. One such innovation has been the development of the growth-enhanced Atlantic salmon, AquAdvantage Salmon (AAS), which was approved for commercial production and consumption in the US in 2015. AquAdvantage Salmon are raised exclusively in land-based operations using highly efficient […]

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Design and development of pharmacological chaperones to restore function to MC4R mutants responsible for severe early-onset obesity.

“Melanocortin 4 receptor (MC4R) is a is a G protein-coupled receptor (GPCR) and key regulator of energy homeostasis. MC4R mutations represent the largest monogenic cause of obesity, resulting mainly from receptor misfolding and intracellular retention by the cellular quality control system. The efficacy of several lead compounds on restoring the cell surface expression and function […]

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Design and development of pharmacological chaperones to restore function to MC4R mutants responsible for severe early-onset obesity. – Year two

“Melanocortin 4 receptor (MC4R) is a is a G protein-coupled receptor (GPCR) and key regulator of energy homeostasis. MC4R mutations represent the largest monogenic cause of obesity, resulting mainly from receptor misfolding and intracellular retention by the cellular quality control system. The efficacy of several lead compounds on restoring the cell surface expression and function […]

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