Single-molecule analytics of RNA/DNA drug constructs interacting with RNA targets and with lipid nanoparticle delivery vehicles

In this project, the interns will develop a new set of tools and techniques to provide new scientific insights into the detailed interactions that occur between drug and target molecules in the human body. Understanding of these interactions is critical to design better, more effective, and more precisely targeted drugs. The problem is that current […]

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Effets indirects de l’activité Maritimo-Portuaire : Hydrodynamique Appliquée au transport Sédimentaire et à l’Environnement (EMPHASE)

Le développement durable en milieux estuariens est largement impacté par le transport de sédiments cohésifs (vases ou boues). Or l’étude de leurs lois de transport (érosion, sédimentation) se heurte à de nombreuses difficultés à la fois pratiques (prélèvement, mise en place) et fondamentales (transition solide/liquide, rhéologie complexe). Le transport des sédiments est un sujet qui […]

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Moisture accumulation in a cavity-insulated thick-wall assembly with an exterior air barrier system as a result of natural convection in cold climates

The intent of the proposed research project is to measure the performance of a highly-insulated wall assembly system when an exterior air barrier system is used and air movement within and across the wall occurs. In cold climates, the movement of warm, moist air within and across an exterior wall may result in moisture accumulating […]

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Acylketenes in Catalytic Cycloaddition Reactions

The reactivity of acylketenes in carbon-carbon bond forming reaction has been scarcely explored, despite their ease of access and stability. The student funded through this program will investigate the reactivity of these unexplored species in intramolecular transition metal-catalyzed cycloaddition reactions. These studies will establish the reactivity of acylketenes in cycloadditions, and reveal novel reactivity pathways, […]

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Multi-Gram Scale Synthesis, Purification and Formulation of Psilocybin

Mental illness and addiction refer to a wide range of disorders that affects mood, behavior and thinking and thus leads to depression, anxiety disorders, substance use disorder and stress. The psychedelic drug assisted therapy functions as a mental health therapy, which is evolving at a quicker pace nowadays. These drugs are useful in the treatment […]

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Incorporating Hyperflux in a Nanoptics Platform

This project aims to develop a new platform for spectroscopic imaging with optics at the nano-scale. It will involve forming a new relationship between Tornado Spectral Systems, RHK Technologies and the Burch group at the University of Toronto. This relationship will combine their unique expertise to achieve a system with unparalleled performance, able to determine […]

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Development of a Quantitative and Inexpensive Opioid Detector for Clinical Use

The opioid epidemic is a serious health crisis and opioid treatment strategies are at the forefront of efforts to tackle this crisis. Replacement therapy is the current approach taken using medications such as methadone. To be more effective, the dosage needs to be tailored to individual tolerance which requires a point-of-care type analytical measurement of […]

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Solid Waste Management Best Practices: cost effective options to sustainably manage solid waste in the Peace River Regional District

The Peace River Regional District (PRRD) and the University of Northern British Columbia (UNBC), are collaborating on the development of a solid waste management plan (SWMP) whose foundation is based on the five “R”s as outlined in A Guide to Solid Waste Management Planning (2016) produced by the British Columbia Ministry of Environment1. The hierarchy […]

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Simulating dynamics of flux qubits with charge and hybrid flux noise

D-Wave Systems has designed processors based on a scalable architecture that aim to implement quantum annealing, an algorithm that can be used to solve a wide variety of optimization problems. A minimal requirement for a device to perform quantum annealing is that it maintains coherence throughout an appreciable fraction of the annealing protocol. In reality, […]

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In Vacuo Glycation of Insulin

More than 2 million Canadians suffer from diabetes, a disease associated with the body’s inability to produce or effectively use insulin. The high blood sugar levels associated with diabetes can lead to serious complications such as vision loss, kidney failure, cardiovascular problems, and amputation. Therefore, diabetes patients are treated with insulin, with the aim of […]

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Methods for Polymorphic Screening

Many chemical compounds can exist in multiple crystalline forms, which are called polymorphs. Polymorphs have the same composition, but their properties can vary markedly. In many fields, conditions for crystallization are screened exhaustively to generate as many polymorphs as possible, from which the most advantageous form can be selected. In the pharmaceutical industry, for example, […]

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