Over 350 million people worldwide suffer from depression. A key part in diagnosing depression is screening questionnaires, which rely on patient self-reports of the recent past. With the advent of social media and wearable devices, there is an opportunity for a novel approach to detecting when a patient diagnosed with chronic depression becomes acute. In […]

It is estimated that 1 in 2/3 people will be diagnosed with cancer in their lifetime. Cancer is a genetic disease characterized by the uncontrolled growth of cells. While treatments are available for many cancers, remission of the disease, side-effects of the medication, and the onset of resistance by the cancer to the drugs being […]

The aim of the project is to develop molecules capable of treating cancer. Currently, chemotherapeutics used in the clinic kill cancer as well as healthy cells; this broad mechanism of action results in high toxicity to the patient. In contrast, our approach is to generate a targeted therapeutic that will work against STAT5, a specific […]

Many patients who initially respond well to highly efficacious chemotherapy eventually develop resistance and relapse despite continued treatment. These cancers acquire drug resistance to current therapies through various mechanisms such as the acquisition of mutations for example. Furthermore, some promising targets that play a crucial role in the progression of cancer have been deemed undruggable […]

While significant progress has been made in the treatment of certain cancers, many cancers including acute myeloid leukemia and brain cancers, remain largely untreatable. We are developing unique small molecule-based synthetic therapies, which are expected to deliver more effective and less toxic therapies aggressive cancers.