Integration and Application of New HDX-MS Technologies for High Throughput Biopharmaceutical Development and Manufacturing

As pharmaceutical companies look increasingly towards biological macromolecules like antibodies as new drugs, there is a rapidly growing need to be able to characterize these complex ‘drug candidates’ in detail. Rapid Novor, an international leader in antibody sequencing and characterization services, and the Wilson group, an academic leader in the development of HDX technologies, have […]

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Advancing Wastewater Treatment Efficiency: Empowering Data-Driven Modeling with Domain Knowledge Integration

In Canada, ensuring clean and safe water while promoting environmental sustainability is a top priority. While wastewater treatment plants (WWTPs) has been playing a crucial role in public health and environmental protection, but their operational efficiency still needs to be improved. To this end, this research project focuses on harnessing the power of data-driven modeling […]

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Impact of early vaccination during influenza outbreaks

Vaccination is an important preventive measure against influenza infection during both seasonal epidemics and pandemic outbreaks. This research aims to understand the effect of early vaccination during influenza outbreaks. The objectives are to measure the effectiveness of early vaccination in terms of reducing disease burden (e.g., infection, hospitalization). We apply an important methodology, namely mathematical […]

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Combination of different types of gravity observation for precise geoid determination

The Global Positioning System (GPS) has become an indispensable component of both civil and Geomatics practices. However, the GPS observations provide heights that refer to a reference ellipsoid and are not directly suitable for practical purposes. To transform GPS heights into physical (orthometric) heights referenced to an equipotential surface representing mean sea level on land, […]

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Experimental Fluid Mechanics (EFM) software development

In this research endeavor, our goal is to develop user-friendly software tailored for scientists and engineers specializing in the study of fluid dynamics, particularly within oceanic contexts. Imagine it as an adaptable and comprehensive toolkit designed to simplify their intricate experimental tasks. Initially, we will meticulously craft the software, prioritizing ease of use and efficiency. […]

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Design and Analysis of a Platform to Connect Patients, Providers, and their Social Networks

The healthcare system in Canada and world-wide is suffering increased pressure due to an aging population and increased rates of chronic disease. Research shows that self-management and social networks are key indicators for reducing utilization and cost and improving outcomes of healthcare systems. Lifeguard Health Solutions Inc. has developed a mobile health application that uses […]

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Targeting TRAF1 in psoriatic arthritis

There is no cure for psoriatic arthritis (PsA) and current treatments aim at reducing inflammation, slowing the progression of the disease, and avoiding severe damage to the skin and joints. Immune cells contribute to inflammatory cascades in the joints and the skin that produce inflammatory cytokines and lead to severe tissue damage. Current therapies are […]

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