The high throughput sequencing (HTS) platforms generate unprecedented amounts of data that introduce challenges in computational infrastructure. Data management, storage, and analysis become a major logistical undertaking for those adopting the new platforms. The requirement of large investments for this purpose almost signaled the end of the Sequence Read Archive hosted at the NCBI, […]

  Molecular profiles of tumour samples have been widely and successfully used for classification problems. A number of algorithms have been proposed to predict classes of tumor samples based on expression profiles with relatively high performance. However, prediction of response to cancer treatment has proved to be more challenging and novel approaches with improved generalizability […]