Integrating First Principles and Big-Data Analytics for Improved Biomolecular Simulations

Laws of physics combined with computational prowess has allowed us to simulate biological processes at a molecular level, which have a wide range of applications which include guiding experimental observations, designing drugs with molecular precision, and improving bio-sensor technology. However, the existing models use approximations that that limit scope of their applicability, due to the […]

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Synthesis of Thiol-PEG-PBS-grafted gold nanoparticles for the treatment of head-and-neck cancers

Cancer represents a major public health problem, representing about 13% of deaths worldwide, accounting for more than seven million deaths a year. Surgical excision, chemotherapy, and radiotherapy encompass the forefront of antineoplastic therapy; however, it is well known the numerous adverse effects related to these therapeutic modalities. Some treatments have enough potential to help or […]

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The translation and research of a sanskrit manuscript:Vajravali

My research is focused on the proofreading and translation of the sanskrit manuscripture Vajr?v?li,a ritual compendium compiled by the famous abbot of Vikrama?ila monastery, Abhay?karagupta. Vajr?v?li has mainly introduced the process of drawing a mandala.The so-called “mandala” is a pantheon of tantric buddhism,which can be classified into the “drawn mandala”(lekhyamandala) and “envisaged mandala”(bhavyamandala). The objective […]

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Modeling the risk of breakage of beaver dams

Municipalities in Quebec lack tools to effectively anticipate and manage the consequences of beaver dam outburst flooding. When beaver dams fail the resulting flooding can pose a major threat to public safety and public and private infrastructure. A research project lead by Dr. Jan Franssen in partership with OBV RPNS and its Municipal partners is […]

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Démocratie, système électoral et souveraineté populaire. Etude comparative entre les systèmes électoraux canadien et brésilien

Les systèmes électoraux sont des éléments essentiels au fonctionnement des démocraties représentatives, dont la construction varie considérablement, avec des conséquences importantes pour la mise en œuvre de la démocratie. Le système électoral brésilien est reconnu dans le monde entier par son système de vote entièrement électronique, du vote des citoyens au calcul. Au Canada, par […]

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Application of MagLev-based isolation technology for rapid and sensitive detection of Influenza virus

Influenza is a viral pathogen responsible for annually claiming thousands of lives (~650 000 per year) and posing a significant threat to all human life. In Canada, Influenza pandemics lead to direct economic losses including medical costs (estimated mean cost per treatment: $14,612.00), and indirect losses such as substantial workplace absence (Avg 10.8 days). Additionally, […]

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Interdisciplinary Comparative Regional Assessment of Opportunities and Challenges of Alternative Energy Technologies and Their Environmental Impacts In Relation To Energy Transition

The purpose of this study is to explore the opportunities and challenges of alternative/renewable energy technologies in different regions, particularly Alberta and Bavaria (Germany), and their environmental impacts for proper policy decision making in relation to the interface of energy transition, climate change and environmental impact. The project is significant because it will contribute to […]

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NMR Chemical Shift Prediction for Diamagnetic Li-Ion Solid-State Electrolytes

This research is focused on understanding the microscopic mechanisms of lithium ion dynamics in novel solid-state electrolyte materials, which have a wide array of potential applications ranging from electric vehicle batteries to grid storage of renewable energy. A major gap in the development of all-solid-state batteries, which will be safer and more energy-dense than state-of-the-art […]

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Hybrid Bicomponent Fibres for 3D Printing

Hybrid bicomponent fibers are a novel type of intermediate material for the production of thermoplastic polymer composites with continuous fiber reinforcement. Such intermediate materials consist of reinforcing fibers which are individually coated with a thermoplastic polymer sheath. Upon the application of heat and pressure, these sheaths melt, join together and the remaining air between the […]

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Mimicking Lung- and Gut-Pathogen Interactions Using a Hydrogel-Based Mucus Layer

The objective of this research is to investigate long-term interaction between host cell and pathogen. Research will be proceed using ATPS(Aqueous two phase system) and hydrogel. ATPS enable pathogen to form localized biofilm on mammalian cell tissue. To see long-term interaction, biofilm will be stably localized on mammalian cell using hydrogel, which protect mammalian cell […]

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Population pharmacokinetic-pharmacodynamic modeling of mycophenolate and tacrolimus in pediatric kidney transplant recipients

Mycophenolic acid (MPA) and tacrolimus (TAC) are approved for use in post-transplant immunosuppressants to prevent graft rejection after solid organ transplantation. MPA and TAC are frequently used in combination as an immunosuppressive regimen in pediatric kidney transplant recipients. However, these two drugs have narrow therapeutic ranges and large interindividual pharmacokinetic and pharmacodynamic variabilities. What’s more, […]

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