Propriétés immunomodulatrices de l’activité bactéricide de la phospholipase A2-IIA sécrétée sur le microbiote

Nous étudions les interactions entre une protéine bactéricide, la phospholipase A2-IIA sécrétée (sPLA2-IIA), et la flore microbienne intestinale (microbiote) afin d’en évaluer l’effet sur le système immunitaire. Nous avons observé que des souris transgéniques exprimant constitutivement la sPLA2-IIA humaine (sPLA2-IIATGN) présentent un important désordre immunitaire. En tentant de vérifier l’hypothèse que ce désordre est causé […]

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Étude de la dynamique de population des caribous migrateurs de l’Est du Canada à l’aide de données multi-sources et de modèles intégrés de population

Le caribou migrateur de l’Est du Canada est en déclin. En 2017 le comité sur la situation des espèces en péril au Canada a recommandé le statut d’espèce en danger pour ces populations. Comprendre les changements démographiques de ces troupeaux et les effets de l’environnement qui influent est nécessaire pour améliorer la gestion et la […]

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Financial Contagion Measures Based on Co-movements

This project aims to study various aspects related to the contagion of financial crisis between markets, including the improvements on contagion measures, test of the existence of contagion, and the application of contagion measures in portfolio diversification across markets. The contagion of financial crisis is defined as the phenomenon that there is a significant increase […]

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Small-molecule screen revealing apoptosis inhibitors of BAX and BAK

The focus of this project is to screen for small-molecules that may interact with the machinery that controls the decision of life and death in the cell. Diseases can arise from aberrant control of cell life and death like cancer and neurodegeneration. By shutting off the cell death pathway when cells are injured, or stressed […]

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Recurrence Interval of Large Earthquakes in the Eastern Himalaya

I designed my master project for performing paleo-seismological research in the eastern Bhutan, where no instrumental or historic earthquake is known and where a historic surface rupture along the Himalayan front was recently identified. Based on the ages of the known large historic earthquakes in the eastern Himalaya, the newly identified surface rupture could have […]

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Improving flexible, printable electrochromic devices with silver nanowires

An electrochromic device alters its optical properties such as tint or colour through a voltage. They are currently used in car rear-view mirrors, smart windows, electrochromic displays and eyewear. Conventional electrochromic devices are built on glass, but future applications such as foldable displays demand mechanically flexible devices. Furthermore, to reduce manufacturing costs, materials that are […]

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Characterizing the physiological correlates of post-release mortality in a model sportfish species

Recreational angling represents an economically and culturally important activity worldwide. However, stresses associated with catching a fish, particularly exhaustive exercise, can result in an impaired physiological condition and delayed mortality following the fish’s release which are harmful to the fish’s health and well-being. Additionally, because fish are cold-blooded, the degree to which angling affects fish […]

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Résolution temporelle de détecteurs monolithiques et pixellisés pour la tomographie d’émission par positrons avec temps-de-vol ultra-rapide

La tomographie d’émission par positrons (TEP) est une modalité d’imagerie médicale permettant le diagnostic et le suivi de cancers, maladies neurodégénératives et maladies cardiométaboliques. La prochaine percée majeure en imagerie TEP repose sur la mesure de temps-de-vol (TdV) ultra-rapide, nécessitant une excellente résolution temporelle des détecteurs du scanner. Les détecteurs conventionnels ne possèdent malheureusement pas […]

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Application of Global Predictive Real Time Control Strategy to Improve Flooding Prevention Performance of Stormwater Basins

Sustainability as one of the key elements of Smart cities, can be realized by employing Real Time Control Strategies for city’s infrastructures. Nowadays Stormwater management systems play an important role in mitigating the impacts of urbanization on natural hydrological cycle. Besides, these systems have a huge potential to be managed in such a way that […]

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