Astrocyte to Neuron Reprogramming: Characterization and Evaluation of iPhAGE Miniphagemid Constructs – Mediphage Bioceuticals Inc. – September 2024 to April 2025

This project aims to develop a novel gene delivery method for treating brain injury, and neurodegenerative diseases. This method uses a specially designed virus system, called iPhAGE miniphagemids, to deliver genes of interest in a targeted manner. This method is better suited for targeting the brain as the miniphagemids are far more efficient, in comparison […]

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Landscape Changes and Place Making in Santarém Region, Lower Amazon, Brazil. From Late Pre-Columbian until Contact Periods

Despite an increase in the number of archaeological field projects in the Amazon region, few studies have analyzed landscape in order to understand the intricacies of political life of a given complex-society in the Amazonian prehistory. This research will focus on landscape formation and changes to decipher the degree to which the Tapajó group were […]

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Developing an AI learning and training program – Pedagogy focus

Appleby College is in the early stages of developing its AI learning and training program for high-school-age students. The program aims to provide students an interactive platform focusing on AI literacy and competency. AI technology is a trending domain incorporated in every aspect of life. Therefore, ensuring that students understand AI at an earlier age […]

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Software architectures and control systems for interactive sculptural environments

This project will extend and generalize the software architecture that underlies Living Architecture Systems Group installations. These originally incorporated one-off and bespoke software to enable the specific context of the installation. Gradually the software has become more systematized, and some theoretical principles have emerged. This project will focus on extending and generalizing the current software […]

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Visible manifestation of chemical systems in interactive sculptural environments

This project will explore reversible chemical reactions that can be used in interactive installation works to modulate light and enhance viewer experience in these immersive environments. The outcome will benefit the Riverside Architectural Press and the Living Architecture Systems Group by establishing the viability of key components, positioning proof-of-concept prototypes for potential integration into next-generation […]

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Developing and validating an anonymization copilot

Training artificial intelligence and machine learning (AIML) models requires a large amount of data. However, access to data for AIML projects has been problematic in practice, largely due to privacy concerns. One approach to enable data sharing and data access is to anonymize the data. However, in the Canadian context, a national standard and a […]

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Endothelial-fibroblastic cell interactions in fibrosis

Organ fibrosis contributes to the top 10 causes of death in Canada, affects >6.5M North Americans, consumes >$25 billion in global healthcare expenses, and is a major burden for patients, families, and our society. One of the main signals driving fibrosis is persistent and excessive production of the growth factor TGF-beta. The Hinz lab identified […]

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Shape-shifting organelles: How does ER-remodelling affect plastid morphology?

Research Question: How does ER-remodelling affect plastid morphology? The project focuses on unveiling the relationship between the plastid and ER by investigating novel proteins that seem to mediate the contact between both cellular compartments. Besides investigating the possible bridge between organelles key players changing plastid morphological aspects will be analysed in depth to understand if […]

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A participatory citizen engagement analysis tool for co-producing community wellbeing indicators

Existing democratic structures are fragile and insufficient to address the cascading crises of the coming years. Without inclusive opportunities for people to communicate their views in a deliberative way, both communities and policymakers are being held back from co-creating a desirable future for Canada, a need that the Cornerstone Indicator process is aiming to address. […]

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