Projets novateurs réalisés

Explorez des milliers de projets réussis issus de la collaboration entre organisations et talents postsecondaires.

30156 projets achevés

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Projets par catégorie

O-GlcNAc, a novel strategy to treat acute cardiovascular shock and improve survival

Septic shock is an acute pathology that is the leading cause of admission to ICUs across Canada, and the developed world. Unfortunately, no treatment to date has yet to be proven beneficial. Cardiac failure is a major factor in the mortality induced by septic shock. A major player to be targeted in treating this dysfunction are the mitochondria. The Ottawa-Nantes Sepsis Therapy (ONSET) collaboration will bring two groups of cardiovascular experts to address this pressing issue. Together, this research project will look to formulate novel pre-clinical evidence for the cardiac mito-protective effect of O-GlucNAcylating compounds, a post-translational modification proven to be beneficial in early phase sepsis by the Lauzier Lab in Nantes. The expertise of the Burelle Lab (Canada) in mitochondrial bioenergetics, and working with pharma companies who produce said compounds, will lead to a better understanding of the mechanism of septic injury and potential mito-targeted drug therapies.

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Superviseur du corps professoral :

Yan Burelle

Étudiant :

Partenaire :

Nantes Université

Discipline :

Life Sciences

Secteur :

Education

Université :

University of Ottawa

Programme :

Globalink Research Award

Caractérisation des communautés de joueurs pour le jeu vidéo Dead by Daylight

À la sortie d’un jeu vidéo en ligne, une communauté s’organise autour du jeu, créant une culture, des pratiques de jeu, des attentes et des formes d’appropriation qui peuvent diverger des intentions initiales du développeur du jeu, mais qui, pourtant, ont des effets majeurs sur le succès ou non d’un jeu. L’objectif principal de ce projet est alors de caractériser la communauté du jeu vidéo Dead by Daylight (2016) de Behaviour Digital à travers l’analyse des activités des joueurs sur les forums et les réseaux socionumériques ainsi que l’analyse des données de tracking ingame. L’expertise de l’UQAM associée à celle des employés chez Behaviour permettra une connaissance plus approfondie de la communauté de Dead by Daylight, ce qui aidera à la gestion de la communauté, fournira des éléments clefs pour l’amélioration et l’opération en temps réel du jeu et favorisera ainsi le succès à plus long terme de ce jeu.

Voir la description complète du projet
Superviseur du corps professoral :

Maude Bonenfant

Étudiant :

Partenaire :

Behaviour Interactive

Discipline :

Sociology

Secteur :

Arts, entertainment and recreation; Information and cultural industries; Professional, scientific and technical services

Université :

Université du Québec à Montréal

Programme :

Accelerate

Investigating vestibular changes in patients with post-concussion syndrome (PCS) in relation to the comorbid depression

This proposal presents two parallel research projects to develop pattern recognition algorithms using a relatively new technology, Electrovestibulography (EVestGTM)1 for objectively and accurately effect of confounding depression on concussion both when used as a diagnostic tool and also as a treatment recovery tool. EVestG signals are recorded painlessly and non-invasively from the external ear in response to a vestibular stimulus; they are the brain signals modulated by the vestibular response. When concussed, people commonly experience balance (vestibular) problems and dizziness, as well as confused thinking. In our previously funded MITACS projects2 we have shown that EVestG has potentials to be a reliable diagnostic tool for post-concussion syndrome (PCS) and also monitoring its recovery. TO BE CONT’D

Voir la description complète du projet
Superviseur du corps professoral :

Zahra MK Moussavi;Brian Lithgow

Étudiant :

Partenaire :

Riverview Health Centre Foundation

Discipline :

Engineering

Secteur :

Health and Related Sciences & Technology

Université :

University of Manitoba

Programme :

Accelerate

Role of astrocyte CB1 receptor in the regulation of energy balance

Proper functioning of astrocytes and of the endocannabinoid system in the hypothalamus has been strongly linked to feeding behaviour and energy balance in mice. Furthermore, a strong molecular link has been found to connect cannabinoid receptors to leptin (a hunger hormone) receptors in hypothalamic astrocytes. Specifically, deletion of cannabinoid receptors in hypothalamic astrocytes disrupted the formation of leptin receptors and their signalling pathway. The objective of this project is to test the importance of astrocyte cannabinoid receptors in feeding behaviour. The mouse model used for the project permits the inducible deletion of cannabinoid receptors (CB1) in astrocytes, specifically. These CB1 knockout mice will be treated in vivo with a variety of metabolic challenges including fasting and refeeding, acute leptin injection and exposure to high fat diet. TO BE CONT’D

Voir la description complète du projet
Superviseur du corps professoral :

Jaideep Bains

Étudiant :

Partenaire :

Université de Bordeaux

Discipline :

Life Sciences

Secteur :

Université :

University of Calgary

Programme :

Globalink Research Award

Supramolecular Hydrogels as new stimulable drug delivery systems

This project is based on the development of a new spatiotemporal release system for combination of active principle ingredients (API) under mechanical stimuli. The therapeutic schemes for some pathologies is based on the use of combined drugs to improve the efficiency or reduce the risk of resistance (cancer, infection treatments). Moreover, the use of hydrogels as drug delivery systems enables to reduce side effects due to a localized effect. Combining all these elements, the student will work on the formulation of stimulable supramolecular hydrogels. The molecules synthetized in our laboratory have the properties under high stress to go from a gel state to a liquid state. The formulation go back to its initial state (gel) when the stress is removed (just like ketchup). It’s very useful for hydrogel injection. In these news biomaterials, several API will be added to obtain combined therapies. TO BE CONT’D

Voir la description complète du projet
Superviseur du corps professoral :

Chris Flinn

Étudiant :

Partenaire :

Université de Bordeaux

Discipline :

Life Sciences

Secteur :

Université :

Memorial University of Newfoundland

Programme :

Globalink Research Award

Uncertainties in space debris dynamics due to space weather

The increase in Earth-orbiting space debris has been the cause of significant debate over the last decade. More than 29,000 objects larger than 10 cm have been detected in orbit and it is estimated that more than 170 million particles above 1mm populate the near-Earth environment. Potential collisions between active satellites and space debris are thus becoming an increasing threat to space operations. Research into mitigation strategies and debris removal efforts have been plentiful, but accurate knowledge of debris dynamics and prediction of their orbital and attitude motion is crucial for the safety and success of future missions. Many environmental factors affect an orbiting body’s orbit and spin rate, such as aerodynamic drag, solar radiation, and interactions with Earth’s magnetic field. All of these perturbations are highly dependent on disturbances occurring around Earth due to space weather. TO BE CONT’D

Voir la description complète du projet
Superviseur du corps professoral :

Inna Sharf

Étudiant :

Partenaire :

Paris Observatory

Discipline :

Engineering

Secteur :

Université :

McGill University

Programme :

Globalink Research Award

Nano and Macroscale Tribological Investigation of MoS2 and MoST

Since the beginning of space exploration is has become apparent that lubrication between surfaces in space would face many challenges that aren’t relevant on earth. Friction and wear testing on earth has been developed in turn to emulate the conditions that would be faced by solid lubricants in outer space. This requires specific contact geometries and forces, as well as control of environmental conditions including chemistry, pressure, humidity, and temperature. While studies performed in Toronto will allow for nanoscale tribology tests, access to the highly atmosphere-controlled mechanism-scale Tribowave tribometer in Lyon would allow for the currently uninvestigated comparison between the nanoscale evolution of a lubricant and the macroscale effects of an application driven contact. Furthermore, video and chemical analysis of the sample during the tribological contact during testing is a capability unique to the Tribowave tribometer in Lyon. TO BE CONT’D

Voir la description complète du projet
Superviseur du corps professoral :

Tobin Filleter

Étudiant :

Partenaire :

Institut National des Sciences Appliquées de Lyon

Discipline :

Engineering

Secteur :

Université :

University of Toronto

Programme :

Globalink Research Award

DNA as the addressable element in mesoporous silica particles

Oligonucleotides will be structurally integrated within complementary architectures in order to synthesize hybrid nanomaterials featuring biomolecular-driven behavior. We plan to synthesize nanoparticles featuring nucleic acid conjugates embedded in the structural network, so that their dynamics could be programmed for cancer therapy. We intend to make use of the biodegradable organosilica technology developed in De Cola’s laboratory at the University of Strasbourg (UNISTRA), not otherwise available at McGill University. The principal aim would be to exploit physical, chemical and biological properties of nanosystems that will be utilized as drug delivery carriers and functional therapeutics for advanced personalized nanomedicine applications. The outcomes of this experience will provide fundamental knowledge towards developing novel functional nanomaterials that can help to go beyond the state-of-the-art of drug delivery systems currently used for biomedical treatments.

Voir la description complète du projet
Superviseur du corps professoral :

Hanadi Sleiman

Étudiant :

Partenaire :

Université de Strasbourg

Discipline :

Physics

Secteur :

Education

Université :

McGill University

Programme :

Globalink Research Award

Isolation of Lignin from Lignocellulosic Biomass Using Ionic Liquids and Deep Eutectic Solvents and Pyrolysis of the Extracted Lignin

Lignin, a carbon neutral and an underutilized feedstock, can be used to produce a variety of products, such as oils, syngas, benzene, toluene, xylene as well as high molecular weight products such as wood adhesives (binders), carbon fibers and polyurethane foams using thermal, chemical, biological and electro-biochemical processes. Globally, approximately 64 million tonnes of lignin is produced from pulping processes; however, this material is not isolated but instead utilized onsite for heat and power production. Kraft lignin price can range from $260 to 500 per tonne with prices reaching up to $6500 per tonne depending on the product purity. Isolating lignin from agricultural wastes using economical and environmental friendly processes and employing these processes to produce value-added chemicals are important challenges facing the development of lignin based biorefineries.
Recently, solvent extraction has been examined to recover lignin from a variety of renewable biomasses. TO BE CONT’D

Voir la description complète du projet
Superviseur du corps professoral :

Jerald Lalman

Étudiant :

Partenaire :

Université de Lorraine

Discipline :

Engineering

Secteur :

Education

Université :

University of Windsor

Programme :

Globalink Research Award

Rôles des bactériophages dans l’évolution et la virulence de Clostridium difficile

La résistance aux antibiotiques continue de s’accroître à travers le monde et devient inquiétante. Clostridium difficile est une bactérie multi-résistante responsable de nombreuses maladies intestinales pouvant être fatales. En raison des graves symptômes causés par les infections à C. difficile, la qualité de vie des personnes atteintes se trouve grandement réduite. Ces infections sont complexes à traiter entre autres en raison de la résistance aux antibiotiques et les coûts pour le système de santé sont alors très élevés. Cependant, différentes souches de C. difficile démontrent une virulence variable, ce qui veut dire que certaines d’entre elles peuvent causer des symptômes très graves alors que d’autres sont inoffensives. Les raisons qui font que certaines souches sont plus dangereuses restent encore mal comprises. TO BE CONT’D

Voir la description complète du projet
Superviseur du corps professoral :

Louis-Charles Fortier

Étudiant :

Partenaire :

Institut Pasteur

Discipline :

Life Sciences

Secteur :

Professional, scientific and technical services

Université :

Université de Sherbrooke

Programme :

Globalink Research Award

Inferring matter density from halo spatial distribution

The current picture of structure formation in cosmology suggests that initially over-dense regions of dark matter collapse to form halos. These halos also host most of the luminous matter like galaxies. However, we cannot trace the dark matter directly since it does not interact with light. Therefore, the relationship between the underlying cosmic density and the presence of halos remain unclear. Understanding this relationship is of immense importance in inferring the cosmic density field. We propose using a forward modeling method based on Bayesian Inference to reconstruct the mass density field of the local universe. This process involves producing an ensemble of initial conditions and evolving them according to the known physical laws to the present day. These evolved densities can then be compared to the observed reality statistically. TO BE CONT’D

Voir la description complète du projet
Superviseur du corps professoral :

Michael Hudson

Étudiant :

Partenaire :

Université Pierre et Marie Curie

Discipline :

Physics

Secteur :

Education

Université :

University of Waterloo

Programme :

Globalink Research Award

Optimisation du potentiel gros-grain sOPEP et extension en régime tout-atomes

Les protéines sont des nanomachines dont les fonctions, venant de leur structure tridimensionnelle, sont fondamentales à la survie de la cellule. Avec l’amélioration croissante des super-ordinateurs et des algorithmes, les méthodes informatiques deviennent incontournables à l’étude des protéines. Les interactions physiques à l’origine de la structure des protéines sont modélisées à l’aide d’un potentiel. Les potentiels gros-grain OPEP furent appliqués avec succès à l’étude des protéines amyloïdes et à la prédiction de structure tertiaire grâce au programme PEPFOLD. Des améliorations restent toutefois possibles. Dans le cadre de ce projet, je continuerai l’optimisation du potentiel sOPEP, à la base de PEPFOLD, afin d’en améliorer les capacités de prédiction et à étendre son utilisation aux peptides de 51 à 70 acides aminés. Les grandes banques de protéines, sur lesquelles l’optimisation se fera, sont déjà en place. TO BE CONT’D

Voir la description complète du projet
Superviseur du corps professoral :

Normand Mousseau

Étudiant :

Partenaire :

Université de Paris

Discipline :

Physics

Secteur :

Université :

Université de Montréal

Programme :

Globalink Research Award

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