A Comprehensive Investigation of Combiotics in combination with Conventional Antibiotics in a Mouse lung Infection Model with Pseudomonas aeruginosa

This research addresses a persistent threat to individuals with cystic fibrosis—Pseudomonas aeruginosa bacteria, known for biofilm formation and antibiotic resistance. Unlike prior studies on natural products, this initiative explores the combined impact of conventional antibiotics and MHCombiotics Inc.’s unique blend of metalloid and plant-based compounds. Demonstrated effective against P. aeruginosa, this study compares their efficacy to traditional antibiotics, seeking optimal combinations. Using experiments and a P. aeruginosa pneumonia mouse model, the research aims to unveil the anti-inflammatory, antioxidant, and antimicrobial properties of combiotics also presents a promising solution to combat respiratory infections and address antibiotic resistance, potentially enhancing P. aeruginosa infection treatment and offering crucial insights for improved respiratory care.

Faculty Supervisor:

Raymond Turner

Student:

Partner:

MHCombiotic Inc.

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology; Professional, scientific and technical services

University:

University of Calgary

Program: