A four dimensional neurodevelopmental atlas of the mouse brain

Surgical manipulation (e.g., injections, electrode placement) in the developing mouse brain is essential for neuroscientists in order to study the structure and function of the brain and behaviour. Unfortunately, most atlases used in targeting are based on static adult mouse anatomical brain features. Here we propose the use of 4-dimentional (4D) brain atlases (time being the 4th dimension) in the most common used strains of mice that will aid researchers in targeting regions of interest in the brain as the animals develop. The 4D atlas will have the next generation labeling from the Allen Institute such as gene expression and cell type superimposed over the age related templates. In conjunction with new robotic surgical systems for small animals, we see these atlases as aiding neuroscientists in targeting more accurately their anatomical structures for helping with all types of neuroscience research and disease.

Faculty Supervisor:

Mallar Chakravarty

Student:

Partner:

Rogue Research Inc

Discipline:

Life Sciences

Sector:

Manufacturing; Professional, scientific and technical services

University:

McGill University

Program: