AAV6.2FF production and purification from lab-scale to pre-GMP small-scale

This research project is focused on improving a potential treatment for life-threatening lung disorders through gene therapy, which involves using a genetically engineered virus (a viral vector) to deliver a healthy copy of the problematic gene to the patient’s lung cells.

Our project has three main goals. First, we want to increase the production capacity for the viral vector we use for gene therapy. To do this, we are testing different ways to grow the virus in the lab and make sure it works well in the patient’s lung cells.

Second, we want to make sure the virus we use is very pure and safe. We use advanced methods to clean the virus and make sure it’s free from any harmful substances. This is really important to make sure the treatment is safe and effective.

Finally, we want to make the whole process of making this virus follow strict rules and guidelines, like the ones used for making medicines. This will help us use the treatment in future clinical trials to test its safety and effectiveness.

Faculty Supervisor:

Denis-Claude Roy

Student:

Partner:

Centre C3i

Discipline:

Life Sciences

Sector:

Manufacturing

University:

Université de Montréal

Program: