Address key problems in therapeutic interventions using nanomedicine

Ever-increasing complexity of high morbidity rate diseases including infections, cancer, atherosclerosis, has posed significant challenges in delivering active pharmaceutical agents at their intended targets. Polymeric soft nanoparticles based therapeutics have provided an advantageous platform, and have provoked the design of tailor-made nanoarchitectures that can load, target and deliver with high efficiency. Using synthetically articulated stimuli responsive macromolecules, we are designing smart nanocarriers that can both help overcome physicochemical obstacles; and deliver sufficient dosage of drug molecules in response to endogenous and exogenous triggers. The goal in this project will be to design and develop an optimized drug delivery platform that could sense multifold aberrations in the physiological environment of disease sites and respond synchronously, for sustained drug delivery, nanoparticle disassembly, and its safe clearance. The purpose will be to simplify the formulation design strategy and remove complexities of synthetic build-up of macromolecular precursors; impart sensitivities to nanoparticles through novel functional group(s); and help expedite clinical therapeutic interventions of lipophilic drugs.

Faculty Supervisor:

Ashok Kakkar

Student:

Partner:

École Nationale Supérieure Matériaux, d'Agroalimentaire et de Chimie

Discipline:

Engineering

Sector:

Nanotechnology; Health and Related Sciences & Technology; Pharmaceuticals

University:

McGill University

Program: