Advanced nanoformulation approaches for anti-biofilm innate defense regulator peptides

In the framework of this project, it is aimed to develop a novel therapeutic approach for the treatment of chronic rhinosinusitis. Since its pathology is complex, application of the conventional antibiotics is not much efficient therefore it is defined as a difficult-to-treat disease. To overcome those challenges encountered in the usage of conventional therapeutic approaches, we are aiming to develop a novel approach that bases on novel technologies. For this purpose, Host Defense Peptides will be used as therapeutic agents which are more promising than conventional antibiotics. To deliver those peptides to the site of the diseases, naturally derived polymer(chitosan)-based nano-sized delivery systems are going to be developed. These nano-sized delivery systems will protect peptides and deliver them to the site of disease safely and enable us to use the full potential of the host defense peptides to treat chronic rhinosinusitis.

Faculty Supervisor:

Ellen Wasan

Student:

Partner:

ABT Innovations Inc.

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

University of Saskatchewan

Program: