An IGF-Trap as novel treatment for cancer and metastasis

The present proposal seeks to address an urgent need to evelop new trugs that target metastatic cancer with high efficacy and specificity. The type 1 insulin like growth factor (IGF-I) is a growth-promoting factor implicated in cancer cell growth and metastasis. The receptor for IGF-I has been validated as a target for anticancer therapy in different tumor types. We recently engineered a soluble human IGF-I receptor decoy )sIGFIR) that has already shown anti-metastatic activity in pre-clinical animal models. Presently, the structure of this molecule is being further modified in order to improve its staility and pharmacological efficacy as part of a $875,000 collaborative project supported

mainly by tbe PSVT -3 program of the MDEIE in Quebec. As an important addition to this

project, the trainees will define the mechanism of action of this potential drug, particularly its

effect on cancer-induced and cancer-independent angiogenesis using in vitro and in vivo models. Their findings will…..

Faculty Supervisor:

Pnina Brodt

Student:

Partner:

MSBi Valorisation

Discipline:

Life Sciences

Sector:

Finance and Insurance