Astrocyte to Neuron Reprogramming: Characterization and Evaluation of iPhAGE Miniphagemid Constructs – Mediphage Bioceuticals Inc. – September 2024 to April 2025

This project aims to develop a novel gene delivery method for treating brain injury, and neurodegenerative diseases. This method uses a specially designed virus system, called iPhAGE miniphagemids, to deliver genes of interest in a targeted manner. This method is better suited for targeting the brain as the miniphagemids are far more efficient, in comparison to traditional methods, at crossing the blood brain barrier. Using this novel strategy, a self renewing brain cell type called astrocytes will be converted into neurons, through the delivery of genes called NeuroD1 and Sox2. Through the findings made in this project, we aim to mitigate the consequences linked to neuronal loss in various diseases, offering a novel approach for therapeutics.

Faculty Supervisor:

Michael Beazely

Student:

Partner:

Stem Cell Network;Mediphage Bioceuticals Inc

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

University of Waterloo

Program: