Bioactive nanoparticles-based domiciliary oral gel with antimicrobial, immunomodulatory and antioxidant activity for periodontal therapy

Periodontal diseases are among the most common diseases in the population. According to the Canadian Dental Association, around 7 in 10 Canadians suffer from some form of gum disease at some point in their lives. They are characterized by inflammation and destruction of tooth supporting structures. Their progression is determined by the interaction between microbes and the host immune response. Recently, locally administered therapies have been proposed as a support to the gold standard treatment scaling and root planning, but no consensus on their effectiveness is present. In this project, we aim to characterize and optimize the formulation of bioactive engineered nanoparticles-based domiciliary oral gel that provides antimicrobial effect against microbes as well as anti-inflammatory and antioxidant effect to protect the host cells for applications in periodontal treatment. The experiments proposed in this project will facilitate clinical translation and commercialization of the oral gel.

Faculty Supervisor:

Anil Kishen

Student:

Partner:

Oral Antimicrobials Inc.

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

University of Toronto

Program: